W5. Statistical physics of biophysical systems

Workshop organized by:
A. Deutsch and B. Hatzikirou

Precise regulation of correct cell fate decisions is crucial in the development of multicellular organisms, during which cells differentiate from a single cell to the multitude of cell types that compose the adult organism. Incorrect cell fate decisions can lead to diseases, especially cancer. Experimentally,  cell-decision making has been well studied in the context of a single cell. However, how cells make decisions in their multi-cellular environment still remains elusive. Statistical physics offers a unique methods toolbox to study cell decisions in their multicellular environment since it allows for (i) a low-dimensional description of relevant dynamics, and (ii) coupling between single-cell decisions and the corresponding collective behavior at the multicellular level. Eukaryotic/bacterial phenotypic plasticity and cell fate determination are prime paradigms of cell decision-making impacting all aspects of multicellular behavior, such as collective migration, tissue development or tumor growth. In this mini-symposium, we intend to shed light on the latest developments of the afore-mentioned systems.